TOP 1
I have a ligand, and I want more like it
Aim 1
Expand automated, vendor-neutral, UHPLC-based online separations coupled-to-nMS technology for characterizing biomolecules and complexes
Aim 2
Optimize native separation methods for low volume samples, (e.g., CE (capillary
electrophoresis)-Vibrating Sharp-edge Spray Ionization, nm scale spray tips).
Aim 3
Optimize Variable-temperature Electrospray Ionization (vT-ESI): Probing stability, conformation, composition and dynamics of protein complexes.